Product Description
| Description | Anti-HRas (A146T) Mouse Monoclonal Antibody |
| Another Name | Anti-HRas (Mutated A146T) Mouse Monoclonal Antibody |
| Catalog Number | NL25097 |
| Size: | 100 µl |
| Tested Applications: | ELISA WB IF ELISA:1:500-1:1000 WB:1:500-1:1000 IF:1:50-1:200 |
| Cited Applications: | WB IF |
| Tested Reactivity: | Human , mouse Rat |
| Cited Reactivity: | Human , mouse Rat |
| Gene Symbol: | CTLO; HAMSV; HRAS1; RASH1; p21ras; C-H-RAS; H-RASIDX; C-BAS/HAS; C-HA-RAS1; NS; NS3; OES; CFC2; RALD; K-Ras; KRAS1; KRAS2; RASK2; KI-RAS; C-K-RAS; K-RAS2A; K-RAS2B; K-RAS4A; K-RAS4B; K-Ras 2; ' C-K-RAS; c-Ki-ras; c-Ki-ras2; NS6; CMNS; NCMS; ALPS4; N-ras; NRAS1 |
| Immunogen : | A synthetic peptide from the internal region of HRas which includes the mutation of A146T, human origin |
| Concentration: | 1mg/ml |
| Host/Isotype: | mouse/IgG |
| Class: | monnoclonal |
| Type: | Antibody |
| Predicted mv: | 21 KDa |
| Observed mv: | 21 KDa |
| Uniprot: | P01116 |
| Constituents: | PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol |
| Storage Conditions: | Store at -20°C for one year after shipment |
Background: | The A146T mutation of KRas results in an amino acid substitution at position 146, from an alanine to a threonine. KRAS encodes a protein that is a member of the small GTPase superfamily. Ras A146T mutation results in decreased GTPase activity and constitutive signaling. It can be found in many tumors, such as lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. |
